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Y. Zakharia

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Open access Sep 2026

12 Farnesyl Transferase Inhibitor (FTI) Darlifarnib Combined with Cabozantinib in Renal Cell Carcinoma (RCC): Updated Phase 1a Results from FIT-001

Abstract Background VEGFR- and IO-targeted therapies for metastatic RCC have limitations that can lead to disease progression, highlighting the need for well-tolerated and effective combination strategies. VEGFR-TKI resistance occurs through multiple escape mechanisms, with the mTOR pathway playing a central role in su...

Adanma Ayanambakkam, Y. Zakharia, L. Rosen et al. · 0 citations
Open access Jun 2026

Structured reasoning failures compromise LLM interpretation of clinical oncology notes.

Evaluating and monitoring reasoning fidelity should be a prerequisite for safe deployment of LLMs in oncology decision support, as endpoint accuracy alone may mask clinically meaningful reasoning failures.

Matthew Kenaston, U. Ayub, Mihir Parmar et al. · 0 citations

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