Author

Yu-Zhi Ye

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Oct 2026

Modular Peptide Coatings Regulate the Multistep Biological Performance of Lipid Nanoparticles for Enhanced mRNA Delivery

Lipid nanoparticles (LNPs) are a leading platform for mRNA delivery, yet improving their performance often requires complex chemical modification or reformulation of core components. Here, we report a modular peptide-coating strategy for post-formulation engineering of LNP interfaces through physical assembly. A modu...

Chuan-Mei Tang, Yu-Zhi Ye, Ji-Wei Min et al. · Biomacromolecules · 0 citations

Jul 2026

Self-Assembly of Virus-like Nanoparticles for Nucleic Acid Delivery Based on De Novo Designed α-Helix Peptides.

Efficient and safe delivery of nucleic acids remains a major challenge for clinical translation of gene therapies. Here, we report de novo-designed α-helical peptides that coassemble with lipids and nucleic acids to form core-shell, virus-like nanoparticles (VLNs). The peptides combine a cationic N-terminus for nucleic...

Mingshan Han, Jintao Feng, Xi Rong et al. · Langmuir · 0 citations