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Open access Oct 2026

Metabolic Signatures of Resistance to Mycobacterium Tuberculosis Infection: Insights from a Multi-Country Plasma Metabolomics Study

Background: Tuberculosis (TB) remains the leading infectious disease cause of mortality worldwide. A subset of individuals exposed to Mycobacterium tuberculosis (Mtb) remain TST/IGRA-negative despite sustained exposure, termed "TB resisters". The biological mechanisms underlying this resistance remain poorly understood...

C. Liu, J. M. Collins, M. F. Gyorfy et al. · 0 citations
Open access Oct 2026

Potential effect of replacing sedentary behavior with physical activity on the risk of atrial fibrillation: results from the UK Biobank and REGARDS study

Replacing SB with moderate or higher intensity PA may decrease AF risk in REGARDS, and these substitutions appeared to benefit older individuals and those reporting shorter sleep duration, warranting validation in future studies.

L. Li, A. Shah, Y.-A. Ko et al. · 0 citations
Open access Aug 2026

Leukocyte DNA methylation-based signatures for atherosclerotic cardiovascular disease risk prediction in the Million Veteran Program

DNA methylation-based signatures were associated with incident ASCVD and modestly improved risk prediction beyond that of traditional risk factors, and an agnostic probe reliability-based approach was developed.

A. Barad, D. Khodasevich, P. F. Kho et al. · 0 citations

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