Open access
Sep 2026
A novel recombinant BCG vaccine using a mycobacteriophage promoter shows improved protection against tuberculosis
The limited efficacy of conventional bacillus Calmette–Guérin (BCG) vaccination against adult pulmonary tuberculosis highlights the need for improved vaccine strategies. Genome integration can overcome the plasmid instability of recombinant BCG, but we hypothesized that this approach would be constrained by reduced tra...
Y. Tsukamoto, Yusuke Tsujimura, Tetsu Mukai et al.
· bioRxiv · 0 citations