PSMB5-centered immunotherapy resistance signature predicts prognosis and drives CD8+ T cell exclusion in lung adenocarcinoma
Background: Immune checkpoint inhibitors (ICIs) achieve limited response rates in lung adenocarcinoma (LUAD), and the mechanisms underlying immunotherapy resistance remain poorly understood. Robust predictive biomarkers are urgently needed. Methods: We integrated single cell transcriptomic data, multicohort bulk RNAseq...