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The findings suggest limited overlap in significant metabolite associations across both cognitive performance and neural network activity, which may reflect some degree of domain specificity.
Developing meaningful and effective cognition-oriented treatments to enhance cognition and dementia prevention is a major public health need. This online randomized controlled trial assessed the effects of a new web-based cognitive training platform, the Breakfast Game (BG), which simulates real-life executive control/...
These findings uncover protein signatures that reflect underlying AD biology and provide a foundation for stage-specific biomarkers and therapeutic targeting, with important implications for patient stratification and personalized intervention strategies.
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