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Y. Sasazawa

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Open access Oct 2026

Dibucaine induces autophagic flux and reduces Ser129-phosphorylated α-synuclein in induced pluripotent stem cell–derived neurons with SNCA duplication

The accumulation of α-synuclein (α-syn) in the form of Lewy bodies and Lewy neurites is a neuropathological hallmark of Parkinson’s disease (PD) and is closely associated with disease progression. Targeting the autophagy pathway to enhance the clearance of α-syn aggregates therefore represents a promising therapeutic...

M. Kitagawa, Kengo Miyamoto, Kozo Yoshida et al. · 0 citations

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