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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Y. Pilpel

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Open access Oct 2026

A massively parallel reporter screen defines the syntax of SECReTE, a secretion-enhancing cis regulatory targeting element, in mammalian cells

Variants conferring a high mRNA ER localization score consistently enhanced protein secretion, confirming the mechanistic relationship between mRNA targeting to the ER and secretion efficiency and the correlation between variant performances across both reporters suggests a shared regulatory mechanism.

Gal Haimovich, Gabriela Lobinsky, Shu-Ting You et al. · 0 citations
Open access Oct 2026

A massively parallel reporter screen defines the syntax of SECReTE, a secretion-enhancing cis regulatory targeting element, in mammalian cells

Messenger RNA (mRNA) localization to specific subcellular regions is crucial for proper protein translation and localization. Potential means to localize mRNAs include cis-acting or structural motifs embedded within the sequence. We previously identified a secretion-enhancing cis regulatory targeting element (SECReTE)...

Gal Haimovich, Gabriela Lobinsky, Shu-Ting You et al. · 0 citations
Sep 2026

Encoded and non-genetic protein variants expand human functional proteome.

It is found that the abundance of both genetic and mistranslated protein variants mirrors their allele frequencies in the human population, and it is proposed that non-genetic amino acid substitutions in human proteins provide an abundant source to expanding the functional proteome.

Vyacheslav Tretyachenko, Tehila Leiman, David Morgenstern et al. · 2 citations

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