Y. N. Ramadan

Nanovesicular Spanlastics Thermosensitive Gel for the Ocular Delivery of Voriconazole: Development, Ex Vivo Transcorneal Permeability, and In Vivo Evaluation in a Rabbit Model of Fungal Keratitis

Fungal keratitis remains a leading cause of corneal blindness and eye loss worldwide. Conventional antifungal preparations such as those of voriconazole (VCZ) are often limited by rapid precorneal drug loss and poor corneal penetration, leading to suboptimal therapeutic outcomes. This study aimed to address these limit...

Diet, the Gut Microbiome, and Mental Health: Mechanistic Perspectives

The microbiota–gut–brain axis (MGBA) represents a dynamic, bidirectional communication network linking the gut microbiome with central nervous system function through neural, immune, metabolic, and endocrine pathways. Emerging clinical, observational, and preclinical evidence suggests that special and restrictive dieta...

Pharmaceutical innovation in advanced nanomedicine for the treatment of hypervirulent and multidrug-resistant Klebsiella pneumoniae infections

Emerging CAR-T Cell Therapies for T Cell Malignancies: Innovations, Challenges, and Future Directions

Continued efforts to identify highly specific target antigens, optimize manufacturing processes, enhance safety, and integrate CAR-T therapy with complementary immunotherapeutic approaches are expected to improve clinical outcomes and broaden the application of CAR-T therapy to T-cell malignancies and potentially other...