Author

Y. Kurihara

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Open access Sep 2026

Hox/Meis-dependent gene-regulatory transition underlies cardiopharyngeal neural crest diversification

Neural crest cells (NCCs) are multipotent migratory cells essential for cardiac development, yet the lineage trajectories and gene regulatory networks underlying their differentiation in the cardiopharyngeal region remain unclear. Here, we integrate single-cell RNA-seq, spatial transcriptomics, and multiomic analyses t...

Akiyasu Iwase, Y. Uchijima, Daiki Seya et al. · EMBO Journal · 0 citations

Review Open access Aug 2026

G Protein-Mediated Allosteric Modulation of Ligand Binding in Class A GPCRs: Receptor–Ligand–Transducer Ensembles in Disease and Drug Discovery

G protein-coupled receptors (GPCRs) are dynamic allosteric proteins whose signaling properties are governed by reciprocal communication between extracellular ligand-binding sites and intracellular transducer interfaces. Although classical pharmacological models established the concept that ligand binding and G protein...

Y. Kurihara, Hiroki Kurihara · Pharmaceuticals · 0 citations