PREPARATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF DILTIAZEM HYDROCHLORIDE
The objective of this study was to formulate and evaluate diltiazem hydrochloride (DH) mucoadhesive microspheres (MS) using sodium alginate with pectin, carbopol and HPMC. DH has a half-life of about 6 hrs and is taken twice daily in large number of patients which leads to patient compliance. DH-MS were prepared by ori...