Targeting neutral sphingomyelinase enhances NK cell-mediated immunity via the CXCL10–CXCR3 axis in murine bladder cancer cells
Urothelial carcinoma (UC) often exhibits a “cold” tumor microenvironment with limited immune cell infiltration, leading to resistance to immune checkpoint inhibitors. Neutral sphingomyelinase (nSMase) is a key regulator of extracellular vesicle (EV) biogenesis, and pharmacological inhibition of nSMase using GW4869 ha...