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Author

Y. Komatsu

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Open access Sep 2026

A multicenter retrospective study on the clinical features of patients with human epidermal growth factor receptor 2-positive colorectal cancer (HGCSG2304).

BACKGROUND In metastatic colorectal cancer (mCRC), human epidermal growth factor receptor 2 (HER2)-positive disease is a molecular subtype for targeted therapy; however, real-world data remain limited. METHODS A multicenter retrospective study of patients with HER2-positive mCRC diagnosed between 2010 and 2023 at 14...

S. Kaneko, K. Sawada, K. Hatanaka et al. · 0 citations
Open access Aug 2026

Prognostic impact of circulating tumor RAS and BRAF mutation dynamics in patients with metastatic colorectal cancer

Summary Post-treatment alterations in circulating tumor DNA (ctDNA) hold potential for refining treatment strategies in metastatic colorectal cancer (mCRC). In this multi-institutional study of 1,391 patients from the SCRUM-Japan GOZILA platform, we evaluated the prognostic significance of post-treatment rat sarcoma vi...

H. Osumi, E. Shinozaki, Yoshiaki Nakamura et al. · 0 citations

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