Aging is associated with impairments in cognitive flexibility, a key executive function supported by the medial prefrontal cortex (mPFC), yet the biological mechanisms underlying individual variability in age‐related decline remain poorly understood. Here we investigated behavioral, ultrastructural, and proteomic corre...
Rui Yamada, H. Nagai, C. Numa et al.· Aging Cell· 0 citations
Findings show that the late phase of podocyte-driven CKD involves distributed protein-level remodelling, including an RNA-discordant increase in NR3C2 protein and a candidate plasma-protein-handling signature.
Koichi Ito, Masaki Watanabe, Koyuki Kawamoto et al.· The FEBS Journal· 0 citations
It is demonstrated that chronic stress disrupts central energy metabolism at prefrontal cortical synapses, driving to synaptic pathology and behavioral vulnerability and highlighting synaptic metabolic pathways as promising pharmacological targets for the treatment of stress-related psychiatric disorders.
H. Nagai, K. Ota, C. Numa et al.· International Journal of Neu...· 0 citations
Abstract Advances in mass spectrometry (MS)-based proteomics have enabled the large-scale characterization of posttranslational modifications (PTMs) through affinity-based enrichment. However, this technique introduces a bias towards selectively enrichable modifications, thus leaving oxidative modifications underexplor...
Hiromasa Mitsui, Yusei Okuda, R. Konno et al.· DNA Research· 0 citations
Integrative multi-omics analyses in EL4 T cells reveal unrecognized mechanisms of lipid metabolic adaptation and highlight a regulatory network that coordinates fatty acid uptake in response to impaired lipid synthesis.
Takeru Endo, T. Kanno, R. Konno et al.· Scientific Reports· 0 citations
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