Bulk RNA sequencing dataset of embryonic dorsal telencephalon and cerebral cortex from Sbno1 and Trp53 double conditional knockout mice
Sbno1 (Strawberry notch homolog 1) encodes a nuclear protein expressed in neuronal populations and has been implicated in neurodevelopmental processes. However, bulk transcriptomic datasets from embryonic neural stem cells lacking Sbno1 are limited due to early embryonic lethality in conventional knockout models. To enable stage-specific transcriptomic characterization of Sbno1-deficient neural progenitors, we generated a dorsal telencephalon-specific Sbno1 and Trp53 double conditional knockout (dcKO) mouse model using the Emx1-Cre driver. Bulk RNA sequencing was performed on dorsal telencephalon at embryonic day 12.5 (E12.5) and cerebral cortex at E18.5 from dcKO and littermate control mice. The dataset includes seven biological replicates across two developmental stages and was generated using paired-end 150 bp sequencing on the Illumina NovaSeq X Plus platform. We provide raw sequencing reads, gene-level count matrices, normalized expression values, and associated metadata. Quality control metrics, alignment statistics, sample-level principal component analysis, and replicate concordance analyses are reported to document data quality and reproducibility. This dataset provides a resource for investigating transcriptional dynamics downstream of Sbno1 and Trp53 in embryonic cortical development, and for applying diverse computational and integrative analytical approaches.