Author

Y. Huang

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Open access Sep 2026

Human genetic risk for major depressive disorder implicates motor cortex PVALBâº inhibitory neurons

These findings connect MDD polygenic risk to motor-cortical inhibitory-neuron biology and experimentally tractable circuit mechanisms and provide scDepBrain as a resource for exploring MDD-associated cellular programs across the brain.

Y. Ma, H. Han, C. Chen et al. · medRxiv · 0 citations

Open access Aug 2026

Genetic architecture and biological relevance of intrinsic white matter functional activity

White matter (WM) BOLD signals, long dismissed as non-neuronal noise, are increasingly recognized as intrinsic, anatomically organized functional activity. However, the genetic architecture of intrinsic WM functional activity remains poorly understood. Here, we performed genome-wide and phenome-wide analyses of WM frac...

Y. Huang, A. Toga, L. Zhao · medRxiv · 0 citations

Y. Huang

Human genetic risk for major depressive disorder implicates motor cortex PVALBâº inhibitory neurons

Genetic architecture and biological relevance of intrinsic white matter functional activity

Human genetic risk for major depressive disorder implicates motor cortex PVALBâº inhibitory neurons