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Author

Y. Guan

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Sep 2026

Intraputaminal AAV9 co-delivery of AADC and GDNF in severe AADC deficiency: first-in-human pediatric dose-escalation study.

First-in-human findings support a dual-gene "enzyme restoration plus circuit support" paradigm and provide a strong translational rationale for further clinical development of this next-generation gene therapy for severe AADC deficiency.

Feng Han, Ping-Ping Gao, You-Feng Zhou et al. · 0 citations
Open access Jul 2026

Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.

A double-cutoff analysis suggest that scans in the 11 to 26 Centiloid range should be interpreted with caution depending on the context of use, and positivity cutoffs converged around 18 Centiloids (data-driven) and 27 Centiloids (visual reads).

G. Blazhenets, D. Soleimani-Meigooni, Konstantinos Chiotis et al. · 5 citations

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