Nitroxide Polymer Encapsulating Triptolide for Safe and Effective Small Cell Lung Cancer Therapy by Targeting Energy Metabolism and Pyroptosis.
Small cell lung cancer (SCLC) is highly aggressive neuroendocrine tumor with a paucity of effective therapeutic option. Triptolide (TP), a natural diterpenoid triepoxide, exhibits potent antitumor activities, yet its efficacy and underlying mechanisms in SCLC remain largely undefined. Here, we demonstrate that TP effec...