Author

Xun Tang

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Open access Oct 2026

Multiregional single cell profiling reveals LGALS9 and CD44 mediated niche remodeling crosstalk in metastatic breast cancer

The transition from intraductal to invasive Breast cancer (BC) is driven by complex interactions within the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs), a key stromal component, critically influence extracellular matrix remodeling, immune modulation, and metastatic dissemination. However, the s...

Xun Tang, Ning Jiang, Ying-Xue Cui et al. · Scientific Reports · 0 citations

Open access Oct 2026

A 3D-Printed Biochemical-Mechano-Thermally Responsive Multicellular Tumor Organoid Platform Decodes Biochemical-Physical Regulation of Cancer-Immune Crosstalk and Chemoresistance.

Oral tumors are not shaped by biochemical signals alone; they also evolve within mechanically active and thermally fluctuating microenvironments that critically regulate malignant progression, immune remodeling, and therapeutic resistance. Here, we develop a dynamic bioorthogonal organoid platform that couples a 3D-pri...

Yu-Rui Xu, Zhen Fu, Ke-Rong Chen et al. · Advances in Materials · 0 citations