Xuelei Zhang

Gut microbiota-derived metabolites as context-dependent modulators of Nrf2 signaling in inflammation-driven carcinogenesis

Abstract Chronic inflammation fosters cancer development by sustaining redox imbalance, oxidative stress and persistent tissue damage. A key component to this process is the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2), which coordinates antioxidant and detoxification programs to maintain red...