TREM2⁺ tumor-associated macrophages in cancer: context-dependent biology, biomarkers and precision immunotherapy.
Tumor-associated macrophages (TAMs) are abundant and functionally important components of the tumor microenvironment (TME), yet the molecular programs that distinguish pathogenic macrophage states from tissue-adaptive populations remain incompletely defined. Triggering receptor expressed on myeloid cells 2 (TREM2) has...