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Ambient PM2.5 exposure is associated with clear cell renal cell carcinoma aggressiveness and promotes tumor progression through ROS-mediated AKT/HIF-2α signaling.
Ambient fine particulate matter (PM2.5) is an established environmental health hazard, but its role in clear cell renal cell carcinoma (ccRCC) progression remains incompletely understood. This study integrated epidemiological analysis, mechanistic experiments, transcriptomic profiling, and clinical tissue validation to...