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Open access Aug 2026

Mechanism Investigation of Sophora davidii Flower Extract Against LPS-Induced Acute Lung Injury Based on Network Pharmacology and Molecular Dynamics Simulation

SDFE can ameliorate LPS-induced ALI by inhibiting leukocyte adhesion and reducing oxidative stress, and Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated that leukocyte adhesion and oxidative stress are two key signaling pathways involved in the therapeutic effects of SDFE against ALI.

Cheng Lin, Xue Wang, Dao-Yuan Li et al. · 0 citations
Open access Sep 2026

Artesunate Targets MBL2 to Modulate the TLR4/NRF2/HO‑1 Axis and Ameliorate Podophyllotoxin‑Induced Liver Injury

This study elucidates that ART alleviates DILI through targeting MBL2, thereby dually modulating the NF-κB/NRF2 signaling axis to simultaneously suppress inflammatory responses and enhance endogenous antioxidant defenses.

Ming-Yue Wei, Jun-Jie He, Yan-Zhao Zhang et al. · 0 citations

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