Oct 2026
Dehydrocostus lactone attenuates sepsis-associated neuroinflammation by directly targeting JAK2 identified through thermal proteome profiling.
Investigation of the protective effects and target mechanism of DL on CLP-induced septic mice and LPS-stimulated BV2 microglia found it suppressed JAK2 phosphorylation and downstream STAT3 activation, thereby inhibiting neuroinflammatory responses.
Xue-Ling He, Ting Zhang, Xue-Ting Chen et al.
· Biochemical Pharmacology · 0 citations