Author

Xue-Tao Chen

2 papers indexed here

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Oct 2026

Discovery of Tricyclic Oxazinoquinolinone-Based BCL6 PROTAC Degraders with Potent Activity Against Diffuse Large B-Cell Lymphoma

Overall, compound 15 represents a promising BCL6 PROTAC degrader for DLBCL, which induced rapid and efficient BCL6 degradation in OCI-LY1 cells and displayed potent antiproliferative activity in BCL6-dependent DLBCL cells.

Xue-Tao Chen, Ru-Ju Xu, Xiao-Ran Wang et al. · Journal of Medicinal Chemist... · 0 citations

Open access Sep 2026

Allosteric modulation of YTHDFs by ellagic acid suppresses triple-negative breast cancer via non-canonical activation of the HIF-1α pathway

Summary Triple-negative breast cancer (TNBC) lacks effective targeted therapies, and YTHDF proteins are frequently overexpressed in this malignancy, which correlates with adverse prognosis. Through high-throughput drug screening, we identify ellagic acid (EA) as a compound that binds to YTHDF proteins and disrupts thei...

Jian-Heng Zhou, Yu-Yuan Li, Xue-Tao Chen et al. · Cell Reports Medicine · 0 citations