Multiomics landscape of systemic sclerosis: from autoantibody-positivity to established disease.
OBJECTIVES Systemic sclerosis (SSc) is a progressive autoimmune disease in which pathogenic processes may begin before clinical onset. We aimed to characterise molecular alterations across the spectrum from the asymptomatic SSc-specific autoantibody-positive (SSAP) phase through very early diagnosis of SSc (VEDOSS) to...