Author

Xueping Hu

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Open access Oct 2026

Modular Synthesis of Bridge-Disubstituted Bicyclo[3.1.1]heptanes via Stereoselective Difunctionalization of Tricyclo[4.1.0.02 , 7]heptane.

Scaffolds with flexible bond exit vectors are essential in bioisosteric design, enabling adaptive molecular recognition of conformationally dynamic targets, and fine-tuning key physicochemical properties. Despite this potential, current benzene bioisosteres based on bicyclo[n.1.1]alkanes are confined to three-dimension...

Zhen-Da Fu, Yu-Fei Zhou, Xiao-Wen Gu et al. · Angewandte Chemie · 0 citations

#large language models Jan 2026

Discovery of Novel Nonsteroidal SGRMs of Sulfonamide-2-Oxo-Tetrahydroquinoline Derivatives by Carbonyl Migration.

D8, which contained 2-oxo-tetrahydroquinoline by carbonyl migration form B53, manifests an excellent SGRM with remarkable transrepression potency and optimized binding mode within the GR LBD, underscoring its therapeutic potential and validating the design strategy.

Xiaodong Bao, Yuxin Zhou, Zhaoxu Yang et al. · Journal of Medicinal Chemist... · 1 citation