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Author

Xue Li

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Review Open access Sep 2026

Engram cell vulnerability in neurodegeneration: from mechanistic insights to therapeutic horizons

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD) share progressive memory impairment, yet their upstream pathologies differ. This review synthesizes evidence across these disorders to frame memory decline through engram ensembles and proposes an excita...

Qing-Yu Bai, Yan Yan, Chao-Wen Zeng et al. · 0 citations
Review Open access Sep 2026

Tau phosphorylation in Alzheimer’s disease: emerging mechanisms, network interactions, and therapeutic implications

While amyloid-β (Aβ) has historically dominated the research landscape of Alzheimer’s disease (AD), the limited clinical success of Aβ-centric therapies has redirected focus toward tau pathology, which correlates more robustly with cognitive deterioration and synaptic dysfunction. Transcending the traditional linear...

Xue Li, Lei-Han Zhang, Li-Jun Zhao et al. · 0 citations

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