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Author

Xue Lei

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Open access Aug 2026

Aging-induced hepatocyte CD44 drives IL6/STAT3 signaling that associates with impaired function of neighboring T cells

Liver cancer incidences increase dramatically beyond 55 years of age, suggesting that age-associated changes contribute critically to tumor initiation. However, the mechanisms linking liver aging and cancer initiation remain incompletely defined. This study investigated the role of CD44, a marker of liver tumor-ini...

Armin Gandhi, Kathryn Lande, K. Li et al. · 0 citations
Open access Jul 2026

Mitochondrial metabolism and epigenetic crosstalk drive SASP

It is shown that mitochondrial metabolism provides a second layer of control that enables execution of the inflammatory programme, and a mechanism that selectively controls the inflammatory output of senescent cells is revealed.

Hélène Martini, Jodie Birch, Francisco D M Marques et al. · 3 citations

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