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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Xue-Lan Zhou

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Oct 2026

Structural basis for the broad-spectrum inhibition of the coronavirus main protease by Zevotrelvir.

Beta-coronaviruses have caused three major coronavirus outbreaks, underscoring the urgent need for broad-spectrum antivirals. The coronavirus main protease (Mpro) is an ideal drug target due to its high conservation and absence of human homologs. Zevotrelvir (EDP-235) is an oral Mpro inhibitor with broad-spectrum activ...

Pei Zeng, Li Guo, Wen-Wen Li et al. · 0 citations

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