Xue Gong

Lewis Acid-Catalyzed Vinyl Transfer Using Vinylene Carbonate for Direct Synthesis of C2,C3-Unsubstituted Indoles

C2,C3-unsubstituted indoles are privileged scaffolds in medicinal chemistry, yet their direct assembly from simple C2 feedstocks remains a longstanding synthetic challenge. Herein, we report an example of Y(OTf)3-catalyzed C–H [3 + 2] annulation of anilines with vinylene carbonate, enabling direct access to structura...