Author

Xuege Yang

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Open access Oct 2026

Sestrin1 Ameliorates Senescence and Mediates the Protective Effects of Exercise Against Hepatic Abnormality in C57BL/6J Mice.

It is identified that the Sestrin1/Drp1/cGAS-STING axis plays a pivotal role in liver aging and positioned Sestrin1 as a vital therapeutic target, serving as a key mediator of the anti-aging benefits of exercise training.

Xue-Ge Yang, Yu-Chen Zou, Xiu-Ru Li et al. · Journal of Cellular Physiolo... · 0 citations

Aug 2026

Disuse-induced skeletal muscle IDO1 activation contributes to kynurenine-dependent muscle-liver crosstalk and hepatic oxidative injury.

Physical inactivity and mechanical unloading induce skeletal muscle atrophy and are associated with systemic metabolic disorders, but the molecular basis linking muscle disuse to liver injury remains unclear. Human cohort analyses (CHARLS, NHANES), a mouse hindlimb immobilization model, and multi-level in vitro systems...

Xiu-Ru Li, Jingling Peng, Ya-Ting Huang et al. · Biochimica et Biophysica Act... · 0 citations