Author

Xue-Bing Yan

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Open access Sep 2026

Targeting FEN1 disrupts EIF4A3-mediated MUC1-C autoregulation: a novel strategy to suppress lung adenocarcinoma progression

The FEN1/EIF4A3/MUC1-C axis is established as a novel mechanism driving LUAD progression by concurrently regulating intrinsic malignancy and extrinsic immune evasion, presenting FEN1 targeting as a promising dual-hit therapeutic strategy.

Min Wu, Ben-Meng Wu, Xue-Bing Yan et al. · Cell Death and Disease · 0 citations