Author

Xuanyu Xie

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Open access Sep 2026

A microbiota-substrate-metabolite-target network suggests AKT1-associated links between gut microbiota-derived metabolites and osteoporosis.

OBJECTIVE To build a computational, hypothesis-generating framework that links gut microbiota-related metabolites with osteoporosis (OP) while retaining upstream microbial source and substrate information, and to prioritize candidate host targets, pathways, and modules for subsequent testing. METHODS Metabolites and...

Wen-Xing Zeng, Yuan Gong, Yi-Tao Liao et al. · International Microbiology · 0 citations

Review Open access Aug 2026

Rewiring osteoimmune homeostasis in osteoporosis: T-cell subsets as key regulators and emerging therapeutic targets

Osteoporosis (OP) is a chronic metabolic bone disease characterized by reduced bone mass, microarchitectural deterioration, and an increased risk of fragility fractures. Although conventional views have emphasized the imbalance between osteoblasts and osteoclasts, advances in osteoimmunology have shown that T-cell subs...

Yuan Gong, Wen-Xing Zeng, Yi-Tao Liao et al. · Frontiers in Immunology · 0 citations

Open access Aug 2026

Segment-specific prediction of vertebral collapse severity in osteoporotic fractures

Background Osteoporotic vertebral compression fractures (OVCFs) predominantly cluster at the thoracolumbar junction (T11-L1). Recent studies suggest that both bone quality and muscle health significantly contribute to vertebral collapse. However, among numerous multidimensional imaging metrics, which one can most accur...

Yi-tao Liao, Xing-Guo Zhang, Xuanyu Xie et al. · Frontiers in Endocrinology · 0 citations