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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

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Xuan Shi

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Open access Oct 2026

Design, synthesis, and biological evaluation of 2-aminopyrimidine-5-carboxamide derivatives as potent selective Wee1 inhibitors.

Wee1 is a serine/threonine kinase that plays an important role in regulating DNA damage response and cell cycle checkpoints. Inhibition of Wee1 could abrogate cell cycle arrest, exacerbate DNA damage, and induce mitotic catastrophe and apoptosis. Herein, a novel series of 2-aminopyrimidine-5-carboxamide derivatives wer...

Fei Chen, Yun-Lei Hou, Yue Wu et al. · 0 citations

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