Author

Xuan-Hong He

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Open access Sep 2026

Development and Validation of an Interpretable Machine Learning Model for Predicting Early Pulmonary Metastasis Risk in Osteosarcoma

Pulmonary metastasis in high‐grade conventional osteosarcoma remains a leading cause of treatment failure and mortality. Traditional monitoring methods are insufficient for early detection. This study aims to develop and validate an interpretable machine learning (ML) model using multi‐dimensional data from electronic...

Jian-Hua Mu, Yi-Tian Wang, Han Liu et al. · Cancer Medicine · 0 citations

Open access Jul 2026

Integrated Bulk and Single-Cell Transcriptomics Reveals the C3–C3AR1 Axis as a Candidate Mediator of Coagulome-Immune Crosstalk in Osteosarcoma

The findings imply that within a high coagulation-related transcriptional score group, the interaction between iCAFs and APOE+ macrophages could facilitate OS progression, and the C3–C3AR1 signaling pathway might represent a promising target for future therapeutic strategies and coagulome monitoring in OS.

Jian-Hua Mu, Yi-Tian Wang, Han Liu et al. · Biomedicines · 0 citations