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Open access Oct 2026

Macrophage lipid metabolism and inflammasome activation in rheumatoid arthritis: emerging mechanisms and therapeutic implications

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation, synovial hyperplasia, cartilage destruction, and bone erosion. Within the multicellular RA synovial network, macrophages act as important inflammatory effectors and metabolic sensors whose functional states are...

Hua Hao, Hong-Yu Zhao, Ping Dong et al. · 0 citations
Review Open access Aug 2026

Soft tissue mechanosensing and remodeling: the core regulatory role of Piezo/TRPV4 ion channels

A multiscale framework that spans from molecular mechanisms to organ-level physiology and focuses on the directly mechanosensitive Piezo1/2 channels and the mechano-responsive TRPV4 channel is developed, drawing on their distinct molecular architectures to ground divergent gating properties.

Xuan Fan, Ming-Wei Shi, Zhen Wang et al. · 0 citations

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