NPAS2 attenuates diabetic cardiomyopathy by preserving pyruvate dehydrogenase activity and mitochondrial metabolic homeostasis
Diabetic cardiomyopathy (DCM) is a serious cardiac complication of diabetes, characterized by myocardial metabolic dysregulation, mitochondrial dysfunction, and structural remodeling. Disruption of circadian clock genes has been implicated in metabolic diseases, yet the role of neuronal PAS domain protein 2 (NPAS2)...