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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Xuyu Gu

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3 papers indexed here

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Open access Sep 2026

Targeting LOXL4-driven matrix stiffening with acetyldigoxin restores CD8+ T cell function in lung cancer

Extracellular matrix (ECM) stiffness is known to impair T cell function, yet the underpinning molecular cascade remains undefined. This paper investigates the role of lysyl oxidase–like 4 (LOXL4) in ECM stiffening and CD8+ T cell function in lung cancer. Loxl4 knockout and mouse recombinant LOXL4 protein systems, along...

Xu-Yu Gu, Yi-Fei Zhu, Li Xu et al. · 0 citations
Open access Sep 2026

Targeting NCAPG with Arundanine Suppresses Neutrophil/NET-Mediated Immune Evasion and Enhances CD8+ T Cell Function in Lung Squamous Cell Carcinoma

It is found that NCAPG was significantly upregulated in LUSC, and NCAPG depletion markedly impaired LUSC cell proliferation, migration, and invasion while promoting apoptosis, and targeting NCAPG with Arundanine represents a promising therapeutic strategy to overcome immune evasion and sensitize LUSC to PD-1 blockade.

Xu-Yu Gu, Dong-Ning Lu, Ming Deng et al. · 0 citations
Open access Jul 2026

Novel variants of TP63 identified in Chinese families with split-hand/foot malformation

Three TP63 gene variants were found in the families with SHFM, which expanded the variant spectrum of TP63, providing further evidence for their heterogeneous role in limb and non-limb malformations but also broaden the genetic spectrum of associated disorders.

Xu-Yu Gu, Siyuan Tao, Xiao-Dong Wang et al. · 0 citations

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