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Review Sep 2026

Pyridones and macrocyclic pyrrolidones from marine fungal PKS-NRPS hybrids: biosynthetic origin, bioactivities, and synthetic advances.

Covering: 2002-2025Marine fungi have emerged as a prolific source of structurally unprecedented and biologically potent secondary metabolites, and hybrid polyketide synthase-non-ribosomal peptide synthase (PKS-NRPS) enzymes mainly from marine fungi like symbiotic Aspergillus and deep-sea Penicillium, represent an excep...

Ning Gao, F. Owusu, Jie Yu et al. · 0 citations
Sep 2026

Function-oriented synthesis of marine phidianidine derivatives as potent anti-MRSA agents.

The rapid emergence of multidrug-resistant bacterial pathogens, particularly methicillin-resistant Staphylococcus aureus (MRSA), underscores the critical discovery for new antibiotics with novel scaffolds. We identified lead compound LXW933, which exhibits promising anti-MRSA activity and features a unique 1,2,4-oxadia...

Qiong Wu, Bing-Yuan Yan, Chen Qu et al. · 0 citations

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