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Author

Xu-Lin Liu

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Open access Oct 2026

Sex‐specific brain reserve and progression from mild cognitive impairment to Alzheimer's disease dementia

Findings suggest that females may tolerate greater pathology at early stages but experience faster neurodegeneration later, supporting sex‐specific disease trajectories and highlighting the need for sex‐informed biomarkers.

Xu-Lin Liu, S. D. de Boer, M. Tartaglia · 0 citations
Review Open access Oct 2026

Dynamic remodeling of microglial responses in Alzheimer’s disease: heterogeneous states, spatiotemporal progression, and immunometabolic dysregulation

Alzheimer’s disease (AD) is characterized by progressive neuroinflammation involving microglia whose functional responses extend far beyond the classical M1/M2 framework and form a dynamically heterogeneous continuum. Here, we review recurrent disease-associated microglia (DAM) states and transcriptional programs, incl...

Si-Min Han, Shan-Shan Wang, Jing-Jing Liu et al. · 0 citations

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