Author

Xu-Han Xia

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#protein folding Oct 2026

High-Gain Bacterial RNA Imaging via High-Density Protein Fluorescence In Situ Hybridization

Fluorescence in situ hybridization (FISH) is important for bacterial genotypic analysis; however, the limited number of labels per probe results in insufficient signal gain, compromising the detection of low-abundance RNAs. Here, we present high-density protein FISH (HD-FISH) for high-gain bacterial RNA imaging. Inst...

Qiu-Yu Luo, Jie-Mei Zhuang, Sha Deng et al. · Analytical Chemistry · 0 citations

Review Sep 2026

Advances in cascaded CRISPR for preamplification-free nucleic acid assays.

The design principles and working mechanisms of cascaded CRISPR strategies, encompassing Enzyme-Coupled cascades, Multi-effector class 2 CRISPR cascades, and Type III CRISPR-mediated cascades are introduced, including integration with digital detection platforms and AI-assistant algorithms are discussed.

Ruo-Nan He, Lu Miao, Rui-Jie Deng et al. · Biosensors & bioelectronics · 0 citations