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Review Open access Sep 2026

CD4+ cytotoxic T cells: context-dependent effectors in health and disease

Cytotoxic CD4 + T cells (CD4 + CTLs) have been identified as a specialized effector population characterized by potent cytotoxic machinery, including granzymes, perforin, and the Fas/FasL pathway, that enables the direct killing of MHC-II-expressing target cells. In addition to their classical helper function,...

Hao-Yang Yu, Jia-Xin Liang, Qi-Xuan Gu et al. · 0 citations
Open access Sep 2026

The phospholipase PlcP-mediated membrane lipid remodelling is required for the intracellular survival of Burkholderia cenocepacia.

Burkholderia cenocepacia is a problematic pathogen that infects people with cystic fibrosis and can cause fatal "cepacia syndrome". B. cenocepacia infection is difficult to treat due to the high-level intrinsic resistance of the bacterium to antimicrobials and its ability to survive in macrophages. In this study, we un...

H. Shropshire, Xu Han, Zeng-Sheng Han et al. · 0 citations

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