Cytotoxic CD4
+
T cells (CD4
+
CTLs) have been identified as a specialized effector population characterized by potent cytotoxic machinery, including granzymes, perforin, and the Fas/FasL pathway, that enables the direct killing of MHC-II-expressing target cells. In addition to their classical helper function,...
Hao-Yang Yu, Jia-Xin Liang, Qi-Xuan Gu et al.· Cellular & Molecular Bio...· 0 citations
Burkholderia cenocepacia is a problematic pathogen that infects people with cystic fibrosis and can cause fatal "cepacia syndrome". B. cenocepacia infection is difficult to treat due to the high-level intrinsic resistance of the bacterium to antimicrobials and its ability to survive in macrophages. In this study, we un...
H. Shropshire, Xu Han, Zeng-Sheng Han et al.· Journal of Biological Chemis...· 0 citations
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