Xu-Dong Cai

Immunotherapy of membranous nephropathy: strategic evolution from CD20 monoclonal antibodies to future vaccines

Membranous nephropathy (MN) arises from autoantibody-mediated attack on podocyte antigens, with immune deposits forming subepithelially at the glomerular basement membrane to trigger complement activation and subsequent podocyte damage, eventually manifesting as proteinuria. Traditional therapy hinges on nonspecific im...

Haikun Shenxi Capsule Ameliorates Renal Fibrosis by Modulating Gut Microbiota and Metabolism.

The Role of Natural Products in Ameliorating Mitochondrial Dysfunction in Diabetic Kidney Disease and the Underlying Mechanisms.

Diabetic Kidney Disease (DKD), a prevalent microvascular complication of diabetes mellitus, represents the leading cause of end-stage renal disease worldwide. Its pathogenesis is multifactorial, involving metabolic disturbances, oxidative stress, inflammatory responses, and notably, mitochondrial dysfunction. Mitochond...