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Xiyun Guan

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Jul 2026

Chemical additives-enhanced CRISPR/Cas12a-based RNA detection.

The CRISPR/Cas12a system has revolutionized molecular diagnostics due to its RNA-guided trans-cleavage activity, enabling programmable and highly accurate nucleic acid detection. However, most Cas12a-based assays are optimized for DNA targets, while direct RNA detection constrained by limited sensitivity, typically at...

Jun Chen, Haiyan Zheng, Lucas Guan et al. · 0 citations

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