DNA Origami-Based Multivalent Nanobody Display Platform for Potent Neutralization of Botulinum Neurotoxin Type A.
Botulinum neurotoxins (BoNTs) are the most potent biological toxins discovered to date. Rapid capture and clearance of BoNTs from the bloodstream is a critical strategy for poisoning treatment. Nanobodies, with their high affinity, represent promising molecules for neutralizing BoNTs. Due to its small molecular weight,...