Jun 2026
Prot-ΔΔG: Prediction of protein–protein binding affinity changes upon mutations with pre-training strategies
Prot-ΔΔG is introduced, a purely sequence-based deep learning framework that integrates large-scale pre-trained protein language models with a BiGRU-DBRNN encoder that effectively captures evolutionary and context-dependent patterns without relying on structural inputs.
Han Zhou, Yuxiang Wang, Xiumin Shi et al.
· Journal of Computer-Aided Mo... · 0 citations