Gastric Cancer Stem Cells (GCSCs) contribute to tumor progression and treatment resistance, but their heterogeneity and tumor microenvironment interactions remain unclear. We analyzed GSE163558 single-cell RNA-sequencing data from 10 gastric cancer samples and integrated GCSC-related genes with The Cancer Genome Atlas...
Xin Hu, Shi-Qi Fan, Nai-Qiang Liu et al.· International Journal of Mol...· 0 citations
A multi-omics cellular atlas comprising 88,442 cells and 63 cell subclusters is constructed, revealing complementary malignant-cell heterogeneity at the levels of transcriptional subclusters and recurrent meta-programs of Oral squamous cell carcinoma.
Qing-Kang Meng, Di Huo, Fei Xu et al.· Frontiers in Immunology· 0 citations
SpaPred provides a hypothesis-generating framework for investigating spatial heterogeneity and candidate therapeutic vulnerabilities in HCC and prioritized Oxaliplatin, Belinostat, and Temsirolimus as candidate compounds associated with LE-related transcriptional programs.
Shi-Bo Zhang, Ziqiao Li, Kexin Yu et al.· International Journal of Mol...· 0 citations
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