NAMPT activation protects against myocardial ischemia/reperfusion injury via FSP1-CoQ10 ferroptosis defense.
BACKGROUND Myocardial ischemia/reperfusion injury (MIRI) is characterized by metabolic disturbance, oxidative stress, mitochondrial dysfunction and regulated cardiomyocyte death. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the NAD+ salvage pathway, plays an important role in redox metabo...