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Oct 2026

C-terminus of HSC70-Interacting Protein-Mediated Transforming Growth Factor-β 1 Protein Degradation Underlies the Anti-fibrotic Effects of Verbascoside in Pulmonary Fibrosis.

BACKGROUND Pulmonary fibrosis (PF) is a progressive and fatal interstitial lung disease with limited therapeutic options. Transforming growth factor-β1 (TGF-β1) is a master driver of fibrogenesis, but strategies to effectively degrade this protein remain underexplored. Verbascoside, a natural phenylethanoid glycoside,...

Jiang-Zhou Han, Shan-Shan Lu, Yan-Ping Zhu et al. · 0 citations
Open access Aug 2026

Integrative single-nucleus transcriptomic analysis identifies UBE2C+ proliferative tumor cells and immune-stromal regulatory crosstalk in small cell lung cancer

This study identified UBE2C+ proliferative tumor cells as a functionally relevant malignant subpopulation in SCLC and links this state to immune-stromal communication networks within the tumor microenvironment and provides a systems-level framework for investigating the cancer-immunity regulome in SCLC.

Hong-Ling Jia, Yongxuan An, Bing Chen et al. · 0 citations

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